# DSIP Peptide Research References

> Complete citation list for DSIP peptide research: peer-reviewed studies, clinical trials, and pharmacokinetic investigations with PubMed links and DOIs.

## DSIP peptide references: peer-reviewed citations

The following citations are the source record for all DSIP peptide research summaries on this site. Each citation includes PubMed URL and DOI where available.

[1] Bes F, Hofman W, Schuur J, Van Boxtel C. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology. 1992;26(4):193-197. PMID: 1299794. https://pubmed.ncbi.nlm.nih.gov/1299794/

[2] Schneider-Helmert D, Schoenenberger GA. The influence of synthetic DSIP on disturbed human sleep. Experientia. 1981;37(9):913-917. PMID: 7028502. https://pubmed.ncbi.nlm.nih.gov/7028502/

[3] Schneider-Helmert D. Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia. European Neurology. 1987;27(2):120-129. PMID: 3622582. https://pubmed.ncbi.nlm.nih.gov/3622582/

[4] Kaeser HE. A clinical trial with DSIP. European Neurology. 1984;23(5):386-388. PMID: 6391926. https://pubmed.ncbi.nlm.nih.gov/6391926/

[5] Schneider-Helmert D. Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs. European Neurology. 1986;25(5):373-385. PMID: 3792404. https://pubmed.ncbi.nlm.nih.gov/3792404/

[6] Iyer KS, Marks GA, Kastin AJ, McCann SM. Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat. PNAS USA. 1988;85(10):3653-3656. PMID: 3368469. https://pubmed.ncbi.nlm.nih.gov/3368469/

[7] Iyer KS, McCann SM. Delta sleep-inducing peptide (DSIP) stimulates growth hormone (GH) release in the rat by hypothalamic and pituitary actions. Peptides. 1987;8(1):45-48. PMID: 3575154. https://pubmed.ncbi.nlm.nih.gov/3575154/

[8] Giusti M, Carraro A, Porcella E, Valenti S, Nicora D, Sessarego P, Giordano G. Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women. Psychoneuroendocrinology. 1993;18(8):581-586. PMID: 8475226. https://pubmed.ncbi.nlm.nih.gov/8475226/

[9] Spath-Schwalbe E, Schafer A, Uthgenannt D, Born J, Fehm HL. Delta-sleep-inducing peptide does not affect CRH and meal-induced ACTH and cortisol secretion. Psychoneuroendocrinology. 1995;20(4):431-438. PMID: 7777652. https://pubmed.ncbi.nlm.nih.gov/7777652/

[10] Zlokovic BV, Susic VT, Davson H, Begley DJ, Jankov RM, Mitrovic DM, Lipovac MN. Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain. Peptides. 1989;10(2):249-254. PMID: 2547200. https://pubmed.ncbi.nlm.nih.gov/2547200/

[11] Kato N, Honda Y, Ebihara S, Naruse H, Takahashi Y. Development of an enzyme immunoassay for delta sleep-inducing peptide (DSIP) and its use in the determination of the metabolic clearance rate. Neuroendocrinology. 1984;38(2):126-130. PMID: 6379493. https://pubmed.ncbi.nlm.nih.gov/6379493/

[12] Banks WA, Kastin AJ, Coy DH, Angulo E. Entry of DSIP peptides into dog CSF: role of physicochemical and pharmacokinetic parameters. Brain Research Bulletin. 1986;17(2):155-158. PMID: 3768731. https://pubmed.ncbi.nlm.nih.gov/3768731/

[13] Susic V. The effect of subcutaneous administration of delta sleep-inducing peptide (DSIP) on some parameters of sleep in the cat. Physiology and Behavior. 1987;40(5):569-572. PMID: 3671519. https://pubmed.ncbi.nlm.nih.gov/3671519/

[14] Stanojlovic OP, Zivanovic DP, Susic VT. The effect of delta sleep-inducing peptide on the EEG and power spectra in rat. Indian Journal of Physiology and Pharmacology. 2000;44(3):275-284. PMID: 11214497. https://pubmed.ncbi.nlm.nih.gov/11214497/

[15] Dick P, Grandjean ME, Tissot R. Successful treatment of withdrawal symptoms with delta sleep-inducing peptide. Neuropsychobiology. 1983;10(4):233-237. PMID: 6328354. https://pubmed.ncbi.nlm.nih.gov/6328354/

[16] Dick P, Costa C, Fayolle K, Grandjean ME, Khoshbeen A, Tissot R. DSIP in the treatment of withdrawal syndromes from alcohol and opiates. European Neurology. 1984;23(5):364-371. PMID: 6548969. https://pubmed.ncbi.nlm.nih.gov/6548969/

[17] Schneider-Helmert D. Effects of DSIP on narcolepsy. European Neurology. 1984;23(5):353-357. PMID: 6548968. https://pubmed.ncbi.nlm.nih.gov/6548968/

[18] Larbig W, Gerber WD, Kluck M, Schoenenberger GA. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. European Neurology. 1984;23(5):372-385. PMID: 6548970. https://pubmed.ncbi.nlm.nih.gov/6548970/

[19] Ouichou A, Zitouni M, Raynaud F, Simonneaux V, Gharib A, Pevet P. Delta-sleep-inducing peptide stimulates melatonin, 5-methoxytryptophol and serotonin secretion from perifused rat pineal glands. Biological Signals. 1992;1(4):222-231. PMID: 1339175. https://pubmed.ncbi.nlm.nih.gov/1339175/

[20] Iyer KS, McCann SM. Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat. Brain Research Bulletin. 1987;18(4):513-517. PMID: 3121137. https://pubmed.ncbi.nlm.nih.gov/3121137/

[21] Friedman TC, Garcia-Borreguero D, Hardwick D, Akuete CN, Stambuk MK, Dorn LD, Starkman MN, Loh YP, Chrousos GP. Diurnal rhythm of plasma delta-sleep-inducing peptide in humans. Journal of Clinical Endocrinology and Metabolism. 1994;78(3):617-622. PMID: 8175965. https://pubmed.ncbi.nlm.nih.gov/8175965/

[22] Schneider-Helmert D, Hermann E, Schoenenberger GA. The use of DSIP in the correction of phase-shifted insomnia. Deutsche Medizinische Wochenschrift. 1987;112(2):45-49. PMID: 3582201. https://pubmed.ncbi.nlm.nih.gov/3582201/

[23] Schoenenberger GA. Characterization, properties and multivariate functions of delta-sleep-inducing peptide (DSIP). European Neurology. 1984;23(5):321-345. PMID: 6548966. https://pubmed.ncbi.nlm.nih.gov/6548966/

[24] Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of Neurochemistry. 2006;97(2):303-309. PMID: 16539679. https://pubmed.ncbi.nlm.nih.gov/16539679/

[25] Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, et al. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mechanisms of Ageing and Development. 2003;124(6):721-731. PMID: 12782416. DOI: 10.1016/s0047-6374(03)00082-4. https://pubmed.ncbi.nlm.nih.gov/12782416/

[26] Mu X, Qu L, Yin L, Wang L, Liu X, Liu D. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Frontiers in Pharmacology. 2024. DOI: 10.3389/fphar.2024.1439536. https://pmc.ncbi.nlm.nih.gov/articles/PMC11498945/

[27] Tukhovskaya EA, Shaykhutdinova ER, Ismailova AM, Slashcheva GA, Prudchenko IA, Mikhaleva II, Khokhlova ON, Murashev AN, Ivanov VT. DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion. Biomedicines. 2021;9(4):407. DOI: 10.3390/biomedicines9040407. https://pmc.ncbi.nlm.nih.gov/articles/PMC8069497/

[28] Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, Slashcheva GA, Prudchenko IA, Mikhaleva II, Khokhlova ON, Murashev AN, Ivanov VT. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Molecules. 2021;26(17):5173. PMID: 34500605. DOI: 10.3390/molecules26175173. https://pubmed.ncbi.nlm.nih.gov/34500605/

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Nine residues, twenty-five studies, one grid — the DSIP peptide research record indexed by finding, not by vendor.